5100 Santa Monica Boulevard is a prime property located in the highly dense submarket of East Hollywood, which is bordered by Hollywood, Los Feliz, Silver Lake, and Koreatown. The property enjoys a large population of over 78,000 residents living within one mile. The area is highly walkable, with a walk score of 91 out of 100, making it an ideal location for retail businesses. The property is conveniently located just half a mile east of the former SEARS site at 5601 Santa Monica Boulevard, where BARDAS Investment Group and Bain Capital plan to develop a studio campus comprising 600,000 square feet of sound and flex stages, private bungalow space, and creative office space.

The surrounding area has a high demand for residential units, with several large-scale development projects underway. AVA Hollywood at La Pietra Place is a 695-unit development project, The Rise Hollywood is a 369-unit development project, and 6901 Santa Monica Boulevard is a 231-unit development project, all located within a 2-mile radius of the property. Additionally, Reliable Properties is developing "SunWest" at the northwest corner of Sunset & Western, a project that will include 293 residential units above 33,000 square feet of commercial space, while American Commercial Equities is developing 735 residential units accompanied by 95,820 square feet of commercial space at 5420 Sunset Boulevard.